HIF1A, hypoxia inducible factor 1 subunit alpha, 3091

N. diseases: 1044; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0428886
Disease: Mean blood pressure
Mean blood pressure 		0.100 GeneticVariation phenotype GWASDB Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets. 22510845 2012
CUI: C4551637
Disease: Erythrocytosis familial, 1
Erythrocytosis familial, 1 		0.310 Biomarker disease GENOMICS_ENGLAND Clinical utility gene card for: familial erythrocytosis. 22274579 2012
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 Biomarker disease RGD Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species. 17582388 2007
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.600 Biomarker disease RGD Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species. 17582388 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker group RGD Coexistence of hypercholesterolemia and hypertension impairs adventitial vascularization. 11882589 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker group RGD Relative to controls, HIF-1 expression increased fivefold in response to venous hypertension (P < 0.005), with peak expression 1 day later localized to endothelial cells in venules next to the sagittal sinus. 16955051 2006
CUI: C0752308
Disease: Hypoxia-Ischemia, Brain
Hypoxia-Ischemia, Brain 		0.530 Therapeutic disease RGD [Effect of Shenmai injection on expression of hypoxia-inducible factor-1alpha in hypoxic-ischemic brain damage: experiment with rats]. 19595151 2009
CUI: C0752308
Disease: Hypoxia-Ischemia, Brain
Hypoxia-Ischemia, Brain 		0.530 Biomarker disease RGD The requirement of extracellular signal-related protein kinase pathway in the activation of hypoxia inducible factor 1 alpha in the developing rat brain after hypoxia-ischemia. 18210138 2008
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.510 Biomarker disease RGD Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia. 17101276 2007
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.510 Therapeutic disease RGD Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin. 18369388 2008
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.500 Biomarker phenotype RGD Taken together, our results suggest that changes in HIF-1alpha and TGF-beta1 expression after hypoxia play an important role in hypoxia-induced pulmonary hypertension of rats. 17213961 2007
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.500 Biomarker phenotype RGD Our study found that HIF-1alpha, HIF-2alpha and HIF-3alpha may not only confer different target genes, but also play key pathogenetic roles in hypoxic-induced pulmonary hypertension. 16215633 2005
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Biomarker phenotype RGD Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1alpha upregulation. 19727523 2009
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Biomarker phenotype RGD Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1. 12189448 2002
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Therapeutic phenotype RGD [Protective effects of hypoxia-inducible factor-1 alpha on myocardial ischemia/reperfusion injury in rat and the role of protein kinase C in signal pathway]. 20170615 2010
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 Biomarker disease RGD Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model. 12234789 2002
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 Biomarker disease RGD Adaptation to hypoxia in the diabetic rat kidney. 17914354 2008
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.300 Therapeutic disease RGD Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model. 17967803 2008
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.300 Therapeutic disease RGD Adaptation to hypoxia in the diabetic rat kidney. 17914354 2008
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.300 Therapeutic group RGD [Prevention of hepatic tumor growth and metastasis in rats with rapamycin]. 19335982 2009
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.300 Biomarker disease RGD Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. 15247145 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.300 Biomarker disease RGD Two weeks after MI, both HIF-1alpha and HIF-2alpha mRNA were moderately increased in the infarcted left ventricle and noninfarcted left ventricle; HIF-2alpha amplification was also detected in areas of the interventricular septum and the right ventricle. 18484163 2008
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.300 Biomarker disease RGD Regularity of hypoxia inducible factor 1 alpha expression in acute myocardial ischaemia in rats. 17335664 2007
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.300 Therapeutic disease RGD [Prevention of hepatic tumor growth and metastasis in rats with rapamycin]. 19335982 2009